期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 54, 期 2-3, 页码 283-294出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-014-1182-6
关键词
Photoacoustic imaging; Multiscale imaging; Whole-body imaging; Small-animal imaging
类别
资金
- Ministry of Science, ICT and Future Planning (MSIP), Republic of Korea [NIPA-2013-H0203-13-1001, NRF-2011-0030075, NRF-2013K1A3A1A20046921]
- National Research Foundation of Korea [2013K1A3A1A20046921] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different scales. Further, we have extended the field of view of our imaging system to entire bodies of small animals. At different imaging planes, we have noninvasively imaged the major blood vessels (e.g., descending aorta, intercostal vessels, cephalic vessels, brachial vessels, femoral vessels, popliteal vessels, lateral marginal vessels, cranial mesenteric vessels, mammalian vessels, carotid artery, jugular vein, subclavian vessels, iliac vessels, and caudal vessels) as well as intact internal organs (e.g., spleen, liver, kidney, intestine, cecum, and spinal cord) of the animals in vivo. The spectroscopic whole-body photoacoustic imaging clearly reveals the spectral responses of the internal structures. Similar to other existing preclinical whole-body imaging systems, this whole-body photoacoustic tomography can be a useful tool for small-animal research.
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