期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 51, 期 5, 页码 525-535出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-012-1020-7
关键词
Microfluidics; Centrifugal; Compact disc (CD); Burst frequency equation; Passive valve
类别
资金
- University of Malaya
- Ministry of Higher Education High Impact Research [UM/HIR/MOHE/ENG/05]
- University of Malaya Research Grant [UMRG: RG023/09AET]
- National Institute of Health [1 R01 AI089541-01]
- WCU (World Class University) program through National Research Foundation of Korea [R32-2008-000-20054-0]
- Ministry of Education, Science and Technology
- National Research Foundation of Korea [R32-2008-000-20054-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure.
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