期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 49, 期 6, 页码 713-718出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-011-0745-z
关键词
Bioelectric; Voltage pulse; Nanosecond; high intensity; Modeling; Thermal effect
类别
资金
- Old Dominion University
Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.
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