期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 46, 期 7, 页码 659-670出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-008-0349-4
关键词
orthogonal polarized spectral (OPS) imaging; side-stream dark field (SDF) imaging; vessel density; blood velocity; space-time diagram
This study describes a new method for analyzing microcirculatory videos. It introduces algorithms for quantitative assessment of vessel length, diameter, the functional microcirculatory density distribution and red blood-cell (RBC) velocity in individual vessels as well as its distribution. The technique was validated and compared to commercial software. The method was applied to the sublingual microcirculation in a healthy volunteer and in a patient during cardiac surgery. Analysis time was reduced from hours to minutes compared to previous methods requiring manual vessel identification. Vessel diameter was detected with high accuracy (> 80%, d > 3 pixels). Capillary length was estimated within 5 pixels accuracy. Velocity estimation was very accurate (> 95%) in the range [2.5, 1,000] pixels/s. RBC velocity was reduced by 70% during the first 10 s of cardiac luxation. The present method has been shown to be fast and accurate and provides increased insight into the functional properties of the microcirculation.
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