期刊
MEDIATORS OF INFLAMMATION
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/127170
关键词
-
资金
- National Research Foundation
- Korean government [MEST: 2010-0020260, 20120618, 2012M3A9C6049720, MSIFP: 2013R1A1A3008484]
Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by on-off switch signals between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.
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