期刊
MEDIATORS OF INFLAMMATION
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/639712
关键词
-
资金
- National Natural Science Foundation of China [30972610, 81273240]
- Jilin Province Science and Technology Agency [20110716]
- Health Department Research Projects in Jilin Province [2009Z054]
- Jilin University [2012206]
Aims. Interleukin-37 (IL-37) is an anti-inflammatory cytokine. This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barre Syndrome (GBS). Methods. The levels of plasma and CSF IL-37, IL-17A, IFN-gamma, and TNF-alpha in 25 GBS patients and 20 healthy controls (HC) were determined by enzyme-linked immunoabsorbent assay and flow cytometric bead array assay, respectively. The values of clinical parameters in the patients were also measured. Results. The concentrations of plasma IL-37, IL-17A, IFN-gamma, and TNF-alpha and CSF IL-37 and IL-17A in patients at the acute phase of GBS were significantly higher than those in the HC. The levels of plasma IL-37, IL-17A, IFN-gamma, and TNF-alpha were positively correlated in those patients, and the levels of CSF IL-37 and IL-17A as well as the levels of plasma TNF-alpha were correlated positively with the GBS disability scale scores (GDSs) in those patients. Treatment with intravenous immunoglobulin significantly reduced the levels of plasma IL-37, IL-17A, IFN-gamma, and TNF-alpha in the drug-responding patients. Conclusions. Our findings indicate higher levels of plasma and CSF IL-37 and IL-17A and other proinflammatory cytokines in patients with GBS.
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