期刊
MEDIATORS OF INFLAMMATION
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/819636
关键词
-
资金
- National Natural Science Foundation of China [30972610]
- Jilin Province Science and Technology Agency [200705128, 20110716]
- Chinese Medical Science and Technology Projects of Jilin Province [08sys-086]
- Health Department Research Projects in Jilin Province [2009Z054]
- Jilin University
Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and 20 healthy controls (HC), were analyzed by ELISA. The concentrations of serum IL-2, IFN-gamma, TNF-alpha, IL-4, IL-6, and IL-10, HCV loads, ALT, AST, and HCV-Ab were measured. We found that the levels of serum IL-33 in CHC patients were significantly higher than those of SR-HCV and HC but decreased after treatment with interferon for 12 weeks. More importantly, the levels of serum IL-33 were correlated with the concentrations of ALT and AST in CHC patients. The levels of serum sST2, as a decoy receptor of IL-33, were significantly higher in CHC and SR-CHC patients than those in HC, and there was no correlation between the levels of serum sST2 and IL-33. The concentrations of serum IFN-gamma and IL-6 in CHC patients were significantly lower than those of SR-HCV. These data suggest that IL-33 may be a pathogenic factor contributing to CHC-related liver injury.
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