期刊
MEDIATORS OF INFLAMMATION
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/173498
关键词
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资金
- Slovak Research and Development Agency [APVV-0122-06]
- VEGA [1/0348/09]
- Ministry of Education, Slovakia [1/0380/10]
- [PIRG06-GA-2009-256580]
Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 +/- 7.2 years). With increasing body mass index, increases in AT expressions of IL-6, TNF-alpha, and CD68 were observed (P < .001; P = .005; P < .001, resp.), in association with reduced insulin sensitivity (P < .001). No differences were observed between cachectic and normal-weight patients in AT expressions of inflammatory or proapoptotic markers. Adipose tissue CD68 and TNF-alpha expressions predicted insulin sensitivity independently of known confounders (P = .005; P = .025; R-2 = 0.840). Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. Cachectic patients remain insulin sensitive, with no AT upregulation of inflammatory or proapoptotic markers.
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