期刊
MEDECINE ET MALADIES INFECTIEUSES
卷 44, 期 9, 页码 412-416出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.medmal.2014.08.005
关键词
Ebola; Case fatality rate; Meta-analysis
Objective. -Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers. Methods. -We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species. Results. -Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time. Conclusion. -The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time. (C) 2014 Elsevier Masson SAS. All rights reserved.
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