期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 136, 期 -, 页码 138-147出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2014.01.004
关键词
Inflammaging; Metabolic flexibility; Nutrition; Systems biology; Mathematical model
资金
- European Union [266486]
Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.
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