期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 132, 期 4, 页码 154-162出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2011.02.007
关键词
IGF-1; MGF-E peptide; Proliferation; Hypertrophy
资金
- Universite Pierre et Marie Curie (UPMC)
- CNRS
- INSERM
- ANR In-A-Fib
- Association Francaise contre les Myopathies (AFM)
- AIM
- Myoage (EC) [223576]
- MYORES Network of Excellence (EC) [511978]
- AFLD
Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1 Ec, has a unique E domain with a 49 bp insert in humans (52 bp in rodents; IGF-lEb), which results in a reading frame shift during the IGF-1 gene splicing to produce a distinct mature isoform. We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages. We found that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures. It is concluded that the MGF-24aa-E peptide alone has a marked ability to enhance satellite cell activation, proliferation and fusion for muscle repair and maintenance and could provide a new strategy to combat age related sarcopenia without the oncogenic side effects observed for IGF1. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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