期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 132, 期 3, 页码 123-130出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2011.01.005
关键词
Oxidative stress; Telomere length; Oxygen divers; Hematopoietic stem cells
资金
- Israel Science Foundation [542/05]
- Deborah Fund
- Israel Defense Force Medical Corps and Israeli MOD
- Canadian Institutes of Health Research [MOP38075, GMH79042]
- National Cancer Institute of Canada
- Terry Fox Run
Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group. Both groups were exposed to extreme physical activity, as well. Among the divers following the oxidative stress, significant telomere elongation was observed in granulocytes and naive T cells, but not in memory T cells and B cells. Telomere length in granulocytes was mildly elongated in the control group as well, a finding that may relate to the extreme physical activity to which they were exposed. While telomere elongation in naive T cells may be attributed to telomerase activation, we suggest that in granulocytes the elongation results from undifferentiated hematopoietic cells carrying longer telomeres that repopulate the peripheral hematopoietic compartment. This event might be accompanied by enhanced cell division within the repopulating pool. Since the aging of mammalian tissues can be attributed in part to the reduction in the replicative potential of self renewing cells, enhanced cell turnover under conditions of hyperbaric oxidative stress might be directly relevant to tissue and organismal aging. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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