期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 131, 期 7-8, 页码 511-516出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2010.05.001
关键词
Sirtuins; Mitochondria; AceCS2; Acetate; Aging
资金
- Elison Medical Foundation
- J. David Gladstone Institutes
Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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