期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 129, 期 7-8, 页码 441-448出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2008.04.009
关键词
Cockayne Syndrome; oxidative damage; base excision repair; aging
资金
- Intramural NIH HHS [Z01 AG000726-15, Z01 AG000727-15] Funding Source: Medline
Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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