期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 129, 期 1-2, 页码 17-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2007.10.009
关键词
telomere length; aging; premature aging; longevity; genetic factors; heredity; telomerase; proliferation potential
Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of longevity in the human population. On the other hand, telomere shortening is also observed in the course of many aging-associated disorders but determining whether it is a cause or a consequence is not an easy task. Here, we review the most relevant experimental and descriptive data relating telomere length, as a quantitative trait, to aging and longevity. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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