期刊
APPLIED SURFACE SCIENCE
卷 332, 期 -, 页码 62-69出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2015.01.136
关键词
Chitosan; Silver; Hydroxyapatite; Antibacterial; XPS; Cell culture
类别
资金
- National Basic Research Program of China (973 Program) [2007CB936103]
- National Natural Science Foundation of China [61071026]
A biocomposite coating containing chitosan, silver, and hydroxyapatite was developed on anodized titanium substrate by electrochemical deposition. Coatings were characterized by field-emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and polarisation studies. Results showed that the prepared coatings had compact and dense morphology with a thickness of 6.2 +/- 0.7 mu m and that silver was evenly distributed. Testing the prepared coatings with Gram-positive and Gram-negative bacterial strains exhibited antibacterial activity because of the synergistic effect of silver and chitosan. The prepared coatings were also found to be nontoxic to MC3T3-E1 cells. These results suggested that chitosan/silver-hydroxyapatite biocomposite coatings can prevent the bacterial infection of implants. (C) 2015 Elsevier B.V. All rights reserved.
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