期刊
MECHANICS RESEARCH COMMUNICATIONS
卷 42, 期 -, 页码 92-106出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mechrescom.2012.01.007
关键词
Glaucoma; Growth; Remodeling; Sclera; Lamina cribrosa; Myopia
类别
资金
- National Eye Institute, National Institutes of Health, Bethesda, MD [R01-EY18926, R01-EY19333]
- Legacy Good Samaritan Foundation, Portland, OR
- EyeSight Foundation of Alabama
- Research to Prevent Blindness
Glaucoma is a blinding diseases in which damage to the axons results in loss of retinal ganglion cells. Experimental evidence indicates that chronic intraocular pressure elevation initiates axonal insult at the level of the lamina cribrosa. The lamina cribrosa is a porous collagen structure through which the axons pass on their path from the retina to the brain. Recent experimental studies revealed the extensive structural changes of the lamina cribrosa and its surrounding tissues during the development and progression of glaucoma. In this perspective paper we review the experimental evidence for growth and remodeling mechanisms in glaucoma including adaptation of tissue anisotropy, tissue thickening/thinning, tissue elongation/shortening and tissue migration. We discuss the existing predictive computational approaches that try to elucidate the potential biomechanical basis of theses growth and remodeling mechanisms and highlight open questions, challenges, and avenues for further development. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据