期刊
MEASUREMENT SCIENCE AND TECHNOLOGY
卷 23, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-0233/23/3/035301
关键词
sub-micron resolution; confocal micro-PIV; red blood cell; tank-treading motion; translation stage
资金
- Ministry of Education, Culture, Sports, Science, and Technology [17760134, 21760121]
- Asahi Glass Foundation [58]
- Grants-in-Aid for Scientific Research [23760144, 17760134, 21760121] Funding Source: KAKEN
In this study, a translational confocal micro-particle image velocimetry (PIV) system is introduced to measure the microscopic interaction between red blood cells (RBCs) and the surrounding flow. Since the macroscopic behavior of RBCs, such as the tank-treading motion, is closely related to the axial migration and other flow characteristics in arterioles, the measurement method must answer the conflicting demands of sub-micron resolution, continuous measurement and applicability for high-speed flow. In order to avoid loss of the measurement target, i.e. RBCs, from the narrow field of view during high-magnification measurement, the translation stage with the flow device moves in the direction opposite the direction of flow. The proposed system achieves the measurement of higher absolute velocities compared with a conventional confocal micro-PIV system without the drawbacks derived from stage vibration. In addition, we have applied a multicolor separation unit, which can measure different phases simultaneously using different fluorescent particles, in order to clarify the interaction between RBCs and the surrounding flow. Based on our measurements, the tank-treading motion of RBCs depends on the shear stress gradient of the surrounding flow. Although, the relationship between the tank-treading frequency and the shear rate of the surrounding flow is of the same order as in the previous uniform shear rate experiments, our results reveal the remarkable behavior of the non-uniform membrane velocities and lateral velocity component of flow around the RBCs.
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