期刊
MEASUREMENT SCIENCE AND TECHNOLOGY
卷 20, 期 10, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-0233/20/10/104034
关键词
in vivo short echo-time H-1 MRS; quantification of neurochemical profile; macromolecule contribution
资金
- Centre d'Imagerie BioMedicale (CIBM)
- Leenaards and Jeantet Foundations
- EU [MRTN-CT-2006-035801]
Reliable quantification of the macromolecule signals in short echo-time H-1 MRS spectra is particularly important at high magnetic fields for an accurate quantification of metabolite concentrations (the neurochemical profile) due to effectively increased spectral resolution of the macromolecule components. The purpose of the present study was to assess two approaches of quantification, which take the contribution of macromolecules into account in the quantification step. H-1 spectra were acquired on a 14.1 T/26 cm horizontal scanner on five rats using the ultra-short echo-time SPECIAL (spin echo full intensity acquired localization) spectroscopy sequence. Metabolite concentrations were estimated using LCModel, combined with a simulated basis set of metabolites using published spectral parameters and either the spectrum of macromolecules measured in vivo, using an inversion recovery technique, or baseline simulated by the built-in spline function. The fitted spline function resulted in a smooth approximation of the in vivo macromolecules, but in accordance with previous studies using Subtract-QUEST could not reproduce completely all features of the in vivo spectrum of macromolecules at 14.1 T. As a consequence, the measured macromolecular 'baseline' led to a more accurate and reliable quantification at higher field strengths.
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