期刊
MATURITAS
卷 77, 期 2, 页码 163-167出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2013.10.015
关键词
Idiopathic primary ovarian insufficiency; POI; Inhibin alpha; INHA; Polymorphism
资金
- Priority Research Centers Program [2009-0093821]
- Basic Science Research Programs through the National Research Foundation of Korea (NRF) [2012R1A1A2007033, 2013R1A1A2009661]
- Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea [2012R1A1A2007033, 2013R1A1A2009661] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective: The aim of this study was to investigate whether two polymorphisms in the promoter region of inhibin alpha (INHA) are associated with risk of idiopathic primary ovarian insufficiency (POI) in Korean women, which is a controversial topic. Study design: We genotyped the INHA polymorphisms c.-16C > T (rs35118453) and c.-124A > G (rs11893842) of 136 POI patients and 225 controls in Korean women by polymerase chain reaction and restriction fragment length polymorphism analysis. We then compared differences in genotype and allele frequencies (AF) of the polymorphisms between the two groups to determine odds ratios (OR) and 95% confidence intervals (CI) as measures of the strength of association between genotype and POI. Results: There were no significant differences in genotype or AF of the polymorphisms between the POI patients and controls. Haplotype analysis revealed that the T-G haplotype of the two variant alleles was more frequent in POI patients than in the controls (OR = 1.630, 95% CI = 1.081-2.457). Combination genotype analysis showed that the CT + TT/GG genotype frequency was higher in POI patients than in the controls (OR = 2.414, 95% CI = 1.190-4.895). Conclusions: We provide evidence to suggest that when the two variant alleles are combined, the c.-16C > T and c.-124A > G polymorphisms are associated with increased POI risk in Korean women. We postulate that interactions between the INHA polymorphisms may affect POI risk. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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