期刊
MATRIX BIOLOGY
卷 33, 期 -, 页码 16-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2013.07.006
关键词
Extracellular matrix; Elastic fiber; Transforming growth factor beta; Biological evolution; Protein trafficking; Mitochondria
资金
- National Institutes of Health [HL090648]
- Natural Sciences and Engineering Research Council of Canada [RGPIN 355710-13]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL090648] Funding Source: NIH RePORTER
Cutis taxa (CL), a disease characterized by redundant and inelastic skin, displays extensive locus heterogeneity. Together with geroderma osteodysplasticum and arterial tortuosity syndrome, which show phenotypic overlap with CL, eleven CL-related genes have been identified to date, which encode proteins within 3 groups. Elastin, fibulin-4, fibulin-5 and latent transforming growth factor-beta-binding protein 4 are secreted proteins which form elastic fibers and are involved in the sequestration and subsequent activation of transforming growth factor-beta (TGF beta). Proteins within the second group, localized to the secretory pathway, perform transport and membrane trafficking functions necessary for the modification and secretion of elastic fiber components. Key proteins include a subunit of the vacuolar-type proton pump, which ensures the efficient secretion of tropoelastin, the precursor or elastin. A copper transporter is required for the activity of lysyl oxidases, which crosslink collagen and elastin. A Rab6-interacting goglin recruits kinesin motors to Golgi-vesicles facilitating the transport from the Golgi to the plasma membrane. The Rab and Ras interactor 2 regulates the activity of Rab5, a small guanosine triphosphatase essential for the endocytosis of various cell surface receptors, including integrins. Proteins of the third group related to CL perform metabolic functions within the mitochondria, inhibiting the accumulation of reactive oxygen species. Two of these proteins catalyze subsequent steps in the conversion of glutamate to proline. The third transports dehydroascorbate into mitochondria. Recent studies on CL-related proteins highlight the intricate connections among membrane trafficking, metabolism, extracellular matrix assembly, and TGF beta signaling. (C) 2013 Elsevier B.V. All rights reserved.
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