期刊
MATRIX BIOLOGY
卷 37, 期 -, 页码 1-14出版社
ELSEVIER
DOI: 10.1016/j.matbio.2014.07.005
关键词
Matricellular; Thrombospondins; SPARC; Hevin; Tenascins; CCN; Osteopontin; Fibulin; Periostin; R-spondin; Extracellular matrix; Cell adhesion; Regenerative medicine
资金
- NIH [R13DK100244]
The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s to account for the non-lethal phenotypes of mice with inactivated genes encoding thrombospondin-1, tenascin-C, or SPARC. It was also recognized that these extracellular matrix proteins were primarily counter or de-adhesive. This review reappraises the matricellular concept after nearly two decades of continuous investigation. The expanded matricellular family as well as the diverse and often unexpected functions, cellular location, and interacting partners/receptors of matricellular proteins are considered. Development of therapeutic strategies that target matricellular proteins are discussed in the context of pathology and regenerative medicine. (C) 2014 Published by Elsevier B.V.
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