期刊
MATRIX BIOLOGY
卷 39, 期 -, 页码 17-24出版社
ELSEVIER
DOI: 10.1016/j.matbio.2014.08.008
关键词
Mouse; Osteoarthritis; Chondrocytes; Lubricin; Tribology
资金
- NIH/NIAMS [R01AR050180, R42AR057276]
- NCRR COBRE [P20 RR024484]
- CDMRP [PR110746]
Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion. Arthropathy occurring in patients with joint trauma, inflammatory arthritis or genetically mediated lubricin deficiencies have insufficient lubricin to prevent damage to articular cartilage. Recent studies in lubricin null joints indicate that lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. Progress in the production of recombinant forms of lubricin and the successes of lubricin supplementation in small animal models identify rhPRG4 as a potential therapeutic for patients with transient lubricin deficiency in the setting of trauma or autoimmune arthritis. (C) 2014 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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