期刊
MATRIX BIOLOGY
卷 37, 期 -, 页码 157-161出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2014.06.003
关键词
R-spondin; Bone; Osteoblast; Beta-catenin; Matricellular; Thrombospondin
R-spondins are a family of four matricellular proteins produced by a variety of cell-types. Structurally, R-spondins contain a TSR1 domain that retains the tryptophan structure and a modified cysteine-rich CSVCTG region. In addition, the R-spondins contain two furin repeats implicated in canonical Wnt signaling. R-spondins positively regulate canonical Wnt signaling by reducing Wnt receptor turnover and thereby increasing beta-catenin stabilization. R-spondins are prominently expressed in the developing skeleton and contribute to limb formation, particularly of the distal digit. Additionally, results suggest that R-spondins may contribute to the maintenance of adult bone mass by regulating osteoblastogenesis and bone formation. (C) 2014 Published by Elsevier B.V.
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