期刊
MATRIX BIOLOGY
卷 31, 期 3, 页码 178-186出版社
ELSEVIER
DOI: 10.1016/j.matbio.2012.01.006
关键词
Thrombospondins; Calreticulin; EGF receptors; Wound repair; Fibrosis; TGF-beta
资金
- [HL79644]
- [DK078038]
- [HL084223]
- [T32 HL07918]
- [R13 DK089753]
Thrombospondin 1 (TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-beta activation and plays a role in wound healing and fibrosis. Binding of the TSP N-terminal domain to cell surface calreticulin in complex with LDL-receptor related protein 1 stimulates intermediate cell adhesion, cell migration, anoikis resistance, collagen expression and matrix deposition in an in vivo model of the foreign body response. There is also emerging evidence that TSP EGF-like repeats alter endothelial cell-cell interactions and stimulate epithelial migration through transactivation of EGF receptors. The mechanisms underlying these functions of TSP1 and the implications for physiologic and pathologic wound repair and fibrosis will be discussed. (c) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据