期刊
MATRIX BIOLOGY
卷 30, 期 5-6, 页码 356-360出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2011.03.010
关键词
Collagen; Steered Molecular Dynamics; Enzyme mechanokinetics; Tumor microenvironment
资金
- Weill Cornell Graduate School of Medical Sciences and Weill Medical College's Clinical and Translational Science Center NIH-NCRR [TL1RR024998]
- NIH-NIAMS [R21AR051636, R01AR45748]
- NIH-NCRR [C06-RR12538-01]
Collagen cross-linking mechanically strengthens tissues during development and aging, but there is limited data describing how force transmitted across cross-links affects molecular conformation. We used Steered Molecular Dynamics (SMD) to model perpendicular force through a side chain. Results predicted that collagen peptides have negligible bending resistance and that mechanical force causes helix disruption below covalent bond failure strength, suggesting alternative molecular conformations precede cross-link rupture and macroscopic damage during mechanical loading. (C) 2011 Elsevier B.V. All rights reserved.
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