期刊
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
卷 26, 期 4, 页码 297-307出版社
OXFORD UNIV PRESS
DOI: 10.1093/imammb/dqp005
关键词
modeling; optimization; radiotherapy; simulation
A dynamical system model for tumour-immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the immune system-tumor efficiency ratio (ISTER) is introduced. ISTER dependence of treatment success and other features are studied. Radiotherapy treatment dose optimization, following ALARA (As Low As Reasonably Achievable) criterion, as well as a patient classification are drawn from the statistics results.
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