期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 16, 期 1, 页码 67-75出版社
SPRINGER
DOI: 10.1007/s11154-015-9310-7
关键词
Diabetes mellitus; Obesity; Angiogenesis
资金
- National Institutes of Health [EY012231, EY018659, EY019309, GM104934]
- IRRF
- Oklahoma Center for the Advancement of Science AMP
- Technology (OCAST) [HR13-076]
- Juvenile Diabetic Research Foundation (JDRF) [2-SRA-2014-147-Q-R, 3-PDF-2014-107-A-N]
The prevalence of diabetes mellitus and obesity continues to increase globally. Diabetic vascular complications are the main chronic diabetic complications and associated with mortality and disability. Angiogenesis is a key pathological characteristic of diabetic microvascular complications. However, there are two tissue-specific paradoxical changes in the angiogenesis in diabetic microvascular complications: an excessive uncontrolled formation of premature blood vessels in some tissues, such as the retina, and a deficiency in the formation of small blood vessels in peripheral tissues, such as the skin. This review will discuss the paradoxical phenomena of angiogenesis and its underlying mechanism in obesity, diabetes and diabetic complications.
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