期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 16, 期 2, 页码 165-174出版社
SPRINGER
DOI: 10.1007/s11154-015-9318-z
关键词
Fibroblast growth factor 23 (FGF23); Parathyroid Hormone (PTH); Vitamin D; Phosphate; Hypophosphatemic rickets; Chronic Renal Failure; 1-alpha hydroxylase
资金
- Division of Intramural Research, National Institute of Dental and Craniofacial Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. In this review, we discuss the genomic structure, and transcriptional, translational, and posttranslational regulation of FGF23. We describe its interaction with PTH and vitamin D, disorders of altered FGF23 states, and emerging therapies for diseases of FGF23 based upon these findings. This discussion helps redefine the role of PTH and vitamin D in relation to a complex bone-kidney-parathyroid loop, and points to areas within this complicated field in need of further clarification and research.
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