期刊
MATHEMATICAL BIOSCIENCES
卷 257, 期 -, 页码 60-68出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mbs.2014.07.001
关键词
Skin electroporation; Thermodynamic; Stratum corneum; Numerical; Experimental
资金
- European Regional Development Fund (Biomedical Engineering Competence Center, Slovenia) the Slovenian Research Agency [P2-0249]
- New Zealand Royal Society's Marsden Fund
- Short Term Scientific Mission [COST-STSM-TD1104-14357]
- [COST TD1104]
In this study we consider the physics underlying electroporation which is administered to skin in order to radically increase transdermal drug delivery. The method involves the application of intense electric fields to alter the structure of the impermeable outer layer, the stratum corneum. A generally held view in the field of skin electroporation is that the skin's drop in resistance (to transport) is proportional to the total power of the pulses (which may be inferred by the number of pulses administered). Contrary to this belief, experiments conducted in this study show that the application of high voltage pulses prior to the application of low voltage pulses result in lower transport than when low voltage pulses alone are applied (when less total pulse power is administered). In order to reconcile these unexpected experimental results, a computational model is used to conduct an analysis which shows that the high density distribution of very small aqueous pathways through the stratum corneum associated with high voltage pulses is detrimental to the evolution of larger pathways that are associated with low voltage pulses. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据