期刊
MATHEMATICAL BIOSCIENCES
卷 247, 期 -, 页码 38-46出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mbs.2013.10.004
关键词
Hepatitis delta; Hepatitis B; Mathematical model; Lamivudine; HBV; HDV
资金
- NSF [DMS-0436341, DMS-0920744]
- Achievement Rewards for College Scientists (ARCS) scholarship
The hepatitis delta virus (HDV) is a rarest form of viral hepatitis, but has the worst outcomes for patients. It is a subviral satellite dependent on coinfection with hepatitis B (HBV) to replicate within the host liver. To date, there has been little to no modeling effort for HDV. Deriving and analyzing such a mathematical model poses difficulty as it requires the inclusion of (HBV). Here we begin with a well-studied HBV model from the literature and expand it to incorporate HDV. We investigate two models, one with and one without infected hepatocyte replication. Additionally, we consider treatment by the drug lamivudine. Comparison of model simulations with experimental results of lamivudine treatment indicate that infected cell proliferation may play a significant role in chronic HDV infection. Our results also shed light on several questions surrounding HDV and illustrate the need for more data. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据