Design principles for robust biochemical reaction networks: What works, what cannot work, and what might almost work

We bring together recent results that connect the structure of a mass-action reaction network to its capacity for concentration robustness that is, its capacity to keep the concentration of a critical bioactive species within narrow limits, even against large fluctuations in the overall supply of the network's constituents. (C) 2011 Elsevier Inc. All rights reserved.