期刊
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
卷 173, 期 1-3, 页码 182-186出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mseb.2009.12.044
关键词
Carbon nanotubes; Osteoblast; Adhesion; Vinculin
资金
- Japan Science and Technology Agency (JST)
- Ministry of Health, Labour and Welfare of Japan [H18-kagaku-006]
In recent years, carbon nanotubes (CNTs) have been considered potential biomedical materials because of their unique character. The aim of this study was to investigate the response of a human osteoblast-like cell line - Saos-2 - on single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). The surface of a culture dish was coated with CNTs, and Saos-2 cells were cultured for three days. Cell morphology, viability, alkaline phosphatase (ALP) activity, adhesion, and vinculin expression were evaluated. The result showed high cell viability and strong adhesion to MWCNTs. Saos-2 cultured on MWCNTs exhibited vinculin expression throughout the cell body. while the cells attached to SWCNTs and glass were mostly limited to their periphery. Our results suggest that CNT coatings promote cell activity and adhesiveness. These findings indicate that MWCNTs could be used as surface coating materials to promote cell adhesion. (C) 2009 Elsevier B.V. All rights reserved.
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