期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 93, 期 -, 页码 873-879出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.08.044
关键词
Surface modification; Ceramic implants; 3D printing; Antibacterial activity; Biomedical engineering
资金
- National Natural Science Foundation of China [21461015]
- Science Foundation of Jiangxi Provincial Department of Education [KJLD14010, 20153BCB23035]
- major program of Natural Science Foundation of Jiangxi Province [20161ACB21002]
- Foundation of Health and Family Planning Commission of Jiangxi Province [20155246]
- Science Foundation Jiangxi Provincial Department of Traditional Chinese Medicine [2013A243]
- Foundation of The Second Affiliated Hospital of Nanchang University [2016YNZJ12007]
- China Postdoctoral Science Foundation [2017M610402]
- Postdoctoral Science Foundation of Jiangxi Province [2017KY06]
Nowadays, traditional ceramics for bone implants have considerably replaced by metal based biomedical materials, attributing to the friability of ceramics. However, ceramic implants possess excellent biocompatibility and longtime abrasion resistance. They should be more desirable for long-term uses of implants in case their fragility had been overcome. In the present work, inspired from natural rose, a dual-layer-modified ceramic scaffold was constructed by coating a superplastic layer of isocyanate (ISO) resin and a nano Zinc Oxide (nano-ZnO) layer on the ceramic scaffold. The ISO resin modification layer with 1 mm thickness, improved the mechanical properties of ceramic implants 2-3 times, and protect the ceramic implants from broken even drop from 1 m high. Moreover, such dual layered modification exhibited broad spectrum antibacterial behavior. In vivo biocompatible studies demonstrated that there was no obvious noticeable tissue damage in all major organs of mice after the implant surgeries.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据