期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 8, 页码 4816-4824出版社
ELSEVIER
DOI: 10.1016/j.msec.2013.07.044
关键词
Protein/polysaccharide blends; Biodegradable gels; Irradiation crosslinking; Biocompatibility; Wound healing
资金
- National Natural Science Foundation of China [21103004]
- National Key Technology RD Program [2011BAB02B05]
- Foundation for the Development of Strategic Emerging Industries in Shenzhen [JCYJ20120618162346931]
A series of carboxymethyl chitosan (CM-chitosan) and gelatin hydrogels were prepared by radiation crosslinking. A pre-clinical study was performed by implantation model and full-thickness cutaneous wound model in Sprague-Dawley rats to preliminarily evaluate the biocompatibility, biodegradability and effects on healing. In the implantation test, as a component of the hydrogels, CM-chitosan showed a positive effect on promoting cell proliferation and neovascularization, while gelatin was efficient to stabilize the structure and prolong the degradation time. To evaluate the function on wound healing, the hydrogels were applied to the relatively large full-thickness cutaneous wounds (Phi 3.0 cm). Compared with the control groups, the hydrogel group showed significantly higher percentage of wound closure on days 9, 12 and 15 postoperatively, which was consistent with the significantly thicker granulation tissue on days 3 and 6. All results apparently revealed that the radiation crosslinked CM-chitosan/Gelatin hydrogels could induce granulation tissue formation and accelerate the wound healing. (C) 2013 Elsevier B.V. All rights reserved.
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