期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 7, 页码 4055-4062出版社
ELSEVIER
DOI: 10.1016/j.msec.2013.05.050
关键词
Titanium porous structures; Bone ingrowth; Permeability; Additive manufacturing; Selective laser melting
资金
- EPSRC [EP/I02249X/1]
- EPSRC [EP/I020861/1, EP/I02249X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I02249X/1, EP/I020861/1] Funding Source: researchfish
Porous titanium implants are a common choice for bone augmentation. Implants for spinal fusion and repair of non-union fractures must encourage blood flow after implantation so that there is sufficient cell migration, nutrient and growth factor transport to stimulate bone ingrowth. Additive manufacturing techniques allow a large number of pore network designs. This study investigates how the design factors offered by selective laser melting technique can be used to alter the implant architecture on multiple length scales to control and even tailor the flow. Permeability is a convenient parameter that characterises flow, correlating to structure openness (interconnectivity and pore window size), tortuosity and hence flow shear rates. Using experimentally validated computational simulations, we demonstrate how additive manufacturing can be used to tailor implant properties by controlling surface roughness at a microstructual level (microns), and by altering the strut ordering and density at a mesoscopic level (millimetre). (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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