期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 5, 页码 2995-3000出版社
ELSEVIER
DOI: 10.1016/j.msec.2013.03.026
关键词
Bacterial nanocellulose; Wound dressing; Skin transplantation; Evaluation
资金
- National Natural Science Foundation of PR China [20774033, 21074041]
- Fundamental Research Funds for the Central Universities
- Huazhong University of Science and Technology [2010JC016]
- Natural Science of Hubei Province for Distinguished Young Scholars [2008CDB279]
Bacterial nanocellulose (BNC) was biosynthesized by Gluconacetobacter xylinus. The surface area, physicochemical structure and morphology of the materials were characterized. Here provides a method for an efficient production of uniform BNC, which is beneficial for the fast characterization and evaluation of BNC. In vitro cytotoxicity of the materials was evaluated by the proliferation, the adhesion, the viability and the morphology of NIH/3T3 cells. Low cytotoxicity of the BNC was observed, and micrographs demonstrate a good proliferation and adhesion of NIH/3T3 cells on BNC. Large area full-thickness skin defects were made on the back of C57BL/6 mice in animal surgery. The wounds were transplanted with BNC films and the results compared to those in a control group. The rehabilitation of the wound surfaces and the pathological sections of mice were investigated and are discussed. Histological examinations demonstrated faster and better healing effect and lower inflammatory response in the BNC group than those in the control group. Preliminary results on wound dressings from BNC show a curative effect promoting the healing of epithelial tissue. BNC is a promising natural polymer with medical applications in wound dressings. (C) 2013 Elsevier B.V. All rights reserved.
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