期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 5, 页码 2879-2884出版社
ELSEVIER
DOI: 10.1016/j.msec.2013.03.006
关键词
Magnetic particles; Mesoporous silica; Drug delivery; Folic acid
资金
- National Natural Science Foundation of China [20671045, 20971060]
- International Science and Technology Cooperation Project of Changzhou city [CZ20110023]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property. (C) 2013 Elsevier B.V. All rights reserved.
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