期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 33, 期 8, 页码 5064-5070出版社
ELSEVIER
DOI: 10.1016/j.msec.2013.08.042
关键词
Bioabsorbable stent; Magnesium; Corrosion; In vitro-in vivo correlation
资金
- DeVlieg Foundation
- American Heart Association
Correlating the in vitro and in vivo degradation of candidate materials for bioabsorbable implants is a subject of interest in the development of next-generation metallic stents. In this study, pure magnesium wire samples were corroded both in the murine artery (in vivo) and in static cell culture media (in vitro), after which they were subjected to mechanical analysis by tensile testing. Wires corroded in vivo showed reductions in strength, elongation, and the work of fracture, with additional qualitative changes between tensile profiles. The in vivo degradation was 2.2 +/- 0.5, 3.1 +/- 0.8, and 23 +/- 03 times slower than corrosion in vitro in terms of effective tensile strength, strain to failure, and sample lifetime, respectively. Also, a combined metric, defined as strength multiplied by elongation, was 3.1 +/- 0.7 times faster in vitro than in vivo. Consideration of the utility and restrictions of each metric indicates that the lifetime-based multiplier is the best suited to general use for magnesium, though other metrics could be used to deduce the mechanical properties of degradable implants in service. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据