期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 32, 期 2, 页码 390-394出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2011.11.002
关键词
Template-assisted electrostatic spray deposition; Micropattern; Nanocrystal; Hydroxyapatite; Silk fibroin
资金
- National Key Basic Research Program of China [2009CB930000]
- National Natural Science Foundation of China [810714770]
- Shanghai Science & Technology Committee, Shanghai [0852nm03100]
The surface topography plays an important role in bone formation, which may present specific physical cues to cells and tissues and further improve the bioactivity or osteoconduction of the implants. In this report, nano-hydroxyapatite/silk fibroin (n-HA/SF) composite were prepared via a simplified coprecipitation method. Then these nanocrystals were deposited onto Ti alloy substrates via a template-assisted electrostatic spraying deposition (ESD) technique. The output voltage and flow rate were investigated to produce a cone-jet spraying of n-HA/SF suspensions. By using different types of precisely-designed templates (stripe, grid, and ring), the Ti alloy substrates with different micropatterns (stripe, square, and ring) composed of n-HA/SF composite were created. Our results demonstrated that the precisely-designed micropatterns of n-HA/SF composite onto Ti and its alloy substrates could be easily achieved by using template-assisted ESD. (C) 2011 Elsevier B.V. All rights reserved.
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