期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 32, 期 6, 页码 1428-1436出版社
ELSEVIER
DOI: 10.1016/j.msec.2012.04.022
关键词
Carbonated hydroxyapatite; Silane coupling agent; Poly (lactic acid); In vitro degradation; Bioactivity
资金
- Suranaree University of Technology
- National Research Council of Thailand
- Office of the Higher Education Commission (Higher Education Research Promotion and National Research University Project of Thailand)
In this study, effect of treating bovine bone based carbonated hydroxyapatite (CHA) with silane coupling agent on in vitro degradation and bioactivity of PLA composites were investigated. PLA composite specimens containing CHA and silane-treated CHA were immersed in phosphate-buffered solution at 37 degrees C for the periods of time up to 8 weeks. The changes in specimen weights and morphologies, pH of PBS solution and PLA molecular weight were examined. The results showed that the strong interfacial bonding between silane-treated CHA and PLA matrix significantly delayed in vitro degradation of the PLA composites. However, the bioactivity of the PLA/silane treated CHA composites, determined by the formation of poorly crystalline calcium phosphate compounds on the specimen surface after immersion in simulated body fluid (SBF), seemed to be lower than that of the PLA/CHA composite. (C) 2012 Elsevier B.V. All rights reserved.
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