期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 31, 期 7, 页码 1429-1435出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2011.05.010
关键词
Hydrogels; Photoluminescence; Quantum dots; Thermo-sensitive; Drug-release
资金
- Guilin University of Technology [002401003311]
- National Natural Science Foundation of China [21064002]
Multifunctional hydrogels that simultaneously possess semi-interpenetrating networks structure, strong photoluminescence, and temperature sensitivity were successfully fabricated based on the crosslink of poly (acrylamide) (PAAm) in the presence of poly(N-isopropylacrylamide) (PNIPAM) and CdTe quantum dots (QDs) at a mild condition. With the increase of external temperature, the photoluminescence (PL) intensity and emission peak of the hydrogels gradually decreased and red-shifted, respectively. Decreasing the temperature, the PL intensity and emission peak of the hydrogels could back to their initial values again. Moreover, drug-release experiments on the multifunctional hydrogels demonstrated that the release rate can be tuned by the environmental temperature and the content of PNIPAM. In addition, biocompatible hyperbranched polyglycerol functionalized QDs (QD@HPGs) instead of pristine QDs can also be incorporated into the hydrogels, affording biocompatible hydrogels which could still exhibit temperature-sensitive photoluminescence and drug-release behaviors. (C) 2011 Elsevier B.V. All rights reserved.
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