期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 31, 期 6, 页码 1221-1229出版社
ELSEVIER
DOI: 10.1016/j.msec.2010.10.009
关键词
Carbohydrate; Gold; Nanoconjugate; N-Methylmorpholine N-oxide; Self-assembly; Biomaterial
资金
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan [S: 21678002]
- Austrian Christian Doppler Society
- Grants-in-Aid for Scientific Research [21678002] Funding Source: KAKEN
Carbohydrate-conjugated gold nanoparticles (GNPs) and gold nanolayers (GNLs), which have recently attracted increasing attention as innovative nano-biomaterials, were successfully synthesized using carbohydrate thiosemicarbazones in an aqueous N-methylmorpholine N-oxide (NMMO) system. This system can dissolve various types of carbohydrates including structural polysaccharides, e.g., cellulose. We observed that oxidative NMMO solvent unexpectedly promoted the immediate reduction of [(AuCl4)-Cl-III](-) species to nanosized metallic Au-0, that is GNP. One possible mechanism is that the chloride ligand was oxidized to chlorate via the formation of a hypochlorite intermediate. Site-selective S-labeling of sugar reducing ends with thiosemicarbazide may have enabled regulated self-assembly immobilization to the surfaces of GNPs and GNLs. The carbohydrate-gold nanoconjugates possess unique nanoarchitectures and biofunctions for carbohydrate-cell interactions. Novel and simple approaches for the structural design of carbohydrate-decorated GNPs and GNLs in the NMMO system have potential to inspire a new phase in glyco-biomaterials engineering. (C) 2010 Elsevier B.V. All rights reserved.
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