期刊
RESPIROLOGY
卷 20, 期 8, 页码 1282-1284出版社
WILEY-BLACKWELL
DOI: 10.1111/resp.12602
关键词
asthma; clinical allergy and immunology; clinical respiratory medicine; eosinophil; inflammation
Severe or therapy-resistant asthma represents a major problem, and despite advanced treatment, many patients require oral corticosteroids (OCS). We aimed to determine if patients with severe asthma and elevated peripheral blood eosinophils (PBE) could have treatment with OCS adjusted using an algorithm that controlled PBE (<0.2 x 10(9)/L). In 11 patients, the OCS dose was adjusted to suppress PBE, leading to a reduced exacerbation frequency and improvement in asthma symptoms with an overall lower OCS dose.
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