期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 30, 期 3, 页码 437-444出版社
ELSEVIER
DOI: 10.1016/j.msec.2009.12.013
关键词
Electrospinning; Tissue engineering; Microporous materials; Sol-gel growth
资金
- National Natural Science Foundation of China [30670559]
- National Basic Research Program of China (973 Program) [2007CB935603]
- Program for New Century Excellent Talents in Fujian Province University
Our strategy is to design and fabricate biomimetic and bioactive scaffolds that resemble the native extracellular matrix as closely as possible so as to create conducive living milieu that will induce cell to function naturally. In the present study, gelatin/siloxane (GS) hybrids were prepared by a sol-gel processing, and electrospinning technique was used to fabricate GS fibrous mats to support the growth of bone marrow-derived mesenchymal stem cells (BMSCs) for tissue engineering of bone. The results indicate that the porous structure and fiber size of the GS fibrous mats can be fine tuned by varying the viscosity of GS precursor solution. Additionally, the Ca2+-containing GS fibrous mats biomimetically deposited apatite in a simulated body fluid (SBF), as well as stimulating its BMSCs proliferation and differentiation in vitro, thereby dignifying its in vitro bioactivity. (C) 2010 Elsevier B.V. All rights reserved.
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