期刊
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
卷 29, 期 4, 页码 1330-1333出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2008.10.024
关键词
Biomimetic; Tissue Engineering; Hydroxyapatite; Poly (vinyl alcohol); Scaffolds
资金
- Council of Scientific and Industrial Research
- Department of Biotechnology, India
We report here an in situ process to produce nano-composite polymer hydrogels having surfaces patterned with hydroxyapatite (HA) nanoparticles (100 nm). Poly (vinyl alcohol) (PVA) has been used as a hydrogel forming medium. A three step process, comprising precipitation of HA nanoparticles in presence of PVA molecules and freeze thawing of obtained PVA-HA emulsion, followed by critical point drying, has been devised to produce three dimensional nanocomposite hydrogels. Interaction of Ca2+ with oxygen atoms of PVA and the hydrogen bonding characteristic of the polymer have been exploited to have controlled size distribution of HA in a continuous and macroporous network of PVA. A systematic variation in the polymer concentration could be correlated with microstructural features of the hydrogel. (C) 2008 Elsevier B.V. All rights reserved.
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