FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde

In this work, poly (vinyl alcohol) (PVA) hydrogels with different degree of hydrolysis (DH) were prepared by chemical crosslinking with glutaraldehyde (GA). The nanostructure of the resulting hydrogels was investigated by Fourier Transform Infrared Spectroscopy (FTIR) and Synchrotron small-angle X-ray scattering characterization (SAXS). In vitro tests were performed by swelling ratio assays in different pH solutions. The infrared spectra of the crosslinked PVA showed absorption bands of the acetal bridges resulted from the reaction of the GA with the OH groups from PVA. Also the FTIR spectroscopy was used to determine the crystallinity of the PVA film based on the relative intensity of the vibration band at 1141 cm(-1). The results have showed an increase of hydrogel crystallinity with higher DH of PVA. SAXS patterns have clearly indicated important modifications on the PVA semicrystalline structure when it was crosslinked by GA. The swelling ratio was significantly reduced by chemically crosslinking the PVA network. PVA-derived hydrogel with chemically modified network was found to be pH-sensitive, indicating a high potential to be used in drug delivery polymer system. (c) 2007 Elsevier B.V. All rights reserved.