Effect of porous NiTi alloy on bone formation: A comparative investigation with bulk NiTi alloy for 15 weeks in vivo

The purpose of this study is to investigate the effect of porous NiTi alloy on bone formation with a bulk NiTi alloy as a contrast. The porous NiTi alloy prepared by element powder sintering under Ar protection has a porosity of 45% and a mean pore size of 130 mu m, and the pores are highly interconnected. The porous and bulk NiTi alloys were bilaterally implanted into the femurs of rabbits for 15 weeks, The bone-implant interface and bone ingrowth were evaluated by undecalcified histological examination under light and fluorescent microscope as well as environmental scanning electron microscope (ESEM). The results show: osteoblasts are very active with fast proliferation and no adverse tissue reaction occurs for the porous NiTi alloy after 15 weeks implantation; porous NiTi alloy has better ostcoconductivity and osteointegration than the bulk one; the osteoblasts can ingrow the pores of porous NiTi implant, and direct bone-implant interface can be observed by fluorescent light microscope. (C) 2007 Elsevier B.V. All rights reserved.