期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 219, 期 -, 页码 30-35出版社
ELSEVIER
DOI: 10.1016/j.resp.2015.08.002
关键词
Effort independent; Lung heterogeneity; Pulmonary function; Slope-ratio; Spirometry
资金
- Natural Science and Engineering Council of Canada (NSERC)
- Heart and Stroke Foundation of Canada
- Canadian Stroke Network
- Canadian Institutes of Health Research (CIHR) Institute of Circulatory and Respiratory Health
- CIHR Institute of Aging
- Michael Smith Foundation for Health Research (MSFHR)
- NSERC
- Providence Health Care Research Institute
- St. Paul's Hospital Foundation
- MSFHR
Maximal expiratory flow-volume (MEW) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n = 19) and matched healthy controls (n = 15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90 +/- 0.24 vs. 1.28 +/- 0.32) and Beta-angle (160 +/- 6.7 vs. 186 +/- 15.0) compared to healthy individuals (p <0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p < 0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction. (C) 2015 Elsevier B.V. All rights reserved.
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