期刊
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
卷 13, 期 1, 页码 35-39出版社
UNIV FED SAO CARLOS, DEPT ENGENHARIA MATERIALS
DOI: 10.1590/S1516-14392010000100009
关键词
metallic implants; particles release; in vivo test; Ti6Al4V alloy; stainless steel 316L
Despite the interest in identifying systemic effects caused by the metallic particles released from long term metallic implants in the body, few works support reliable conclusions about the effects of those particles in organs. The aim of the present work is to look for damages in tissues of liver, kidney, lung and heart of rats submitted to injection of Hank's solution contained particles of Ti6Al4V alloy and Stainless Steel 316L, obtained by metal friction. The particles size ranges from 50 to 200 mu m for the Ti alloy and from 100 to 500 mu m for the 316L. Tissues isolated from the organs after the euthanasia were prepared and analyzed in an optical microscope and Energy Dispersive Spectrometer (EDS). Lesions caused by an inflammatory response such as strange body epithelioid granuloma and giant cells were found in some of the tissues containing yttrium and aluminum.
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